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Thursday, July 23, 2020 | History

4 edition of Nucleosides in Cancer Treatment found in the catalog.

Nucleosides in Cancer Treatment

M. Tattersall

Nucleosides in Cancer Treatment

Rational Approaches to Antimetabolite Selectivity (Ludwig symposia)

by M. Tattersall

  • 275 Want to read
  • 3 Currently reading

Published by Academic Pr .
Written in English


The Physical Object
Number of Pages240
ID Numbers
Open LibraryOL7329204M
ISBN 100126838208
ISBN 109780126838206

Langbein, S. et al. Expression of Transketolase TKTL1 Predicts Colon and Urothelial Cancer Patient Survival: Warburg Effect Reinterpreted. Br. J. Cancer. 94, (). Mannava, S. et al. Direct Role of Nucleotide Metabolism in C-Myc-Dependent Proliferation of Melanoma Cells. Cell Cycle. 15, (). Abstract The movement of physiologic nucleosides and nucleoside analogue drugs across biological membranes is mediated by nucleoside transport proteins. In cancer, nucleoside transporters have an important role in maintaining the hyperproliferative state of tumours and are important targets for diagnostic and therapeutic agents.

  Subsequently, the underlying mechanisms, which mediate the anti-cancer effect of Cordyceps militaris on human colorectal cancer, were precisely examined. We found that the anti-cancer effect of nucleosides-enriched ethanol extract of Cordyceps militaris was highly associated with the increased expression of p53, Bax, Bim, Bak, Bad, cleaved. A pair of new anticancer nucleosides based on 1,2,4-triazole nucleosides and 1-((2-hydroxyethoxy) methyl)(phenylthio)-1H-1,2,4-triazolecarboxamide have been synthesized, and have given the corresponding products in excellent yields. Its structures and conformations were confirmed by single crystal X-ray diffraction.

Nucleosides. N-Glycosides of a purine or pyrimidine heterocyclic base and a carbohydrate. The C-N bond involves the anomeric carbon of the carbohydrate. The carbohydrates for nucleic acids are D-ribose and 2-deoxy-D-ribose Nucleosides = carbohydrate + base (Table , p. ) ribonucleosides or 2’-deoxyribonucleosides HO ON HO N N.   Mol. Cancer Ther. 14(12 Suppl. 2), B46–B46 ().Crossref, Google Scholar; 40 Blagden SP, Slusarczyk M, Serpi M et al. First-in-human Phase I study of the nucleotide analogue NUC designed to overcome fluoropyrimidine drug resistance mechanisms. Cancer Res. 76(14 Suppl.), Abstract CT (). Google Scholar.


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Nucleosides in Cancer Treatment by M. Tattersall Download PDF EPUB FB2

Mosconi and colleagues reported a 54% response in stage III/IV non-small-cell lung cancer. 65 In bladder cancer, gemcitabine plus cisplatin (gemcitabine 1 g/m 2 on days 1, 8, 15, plus cispaltin 70 mg/m 2 every 28 days) is now recommended for treatment of advanced disease; this regimen has a better safety profile and is more tolerable than the Cited by: Cytotoxic nucleoside analogues and nucleobases were among the first chemotherapeutic agents to be introduced for the medical treatment of cancer.

This family of compounds has grown to include a variety of purine and pyrimidine nucleoside derivatives with activity in both solid tumours and malignant disorders of the blood.

These agents behave as antimetabolites, compete with Cited by:   Purchase Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications, Volume 45C - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. Get this from a library. Modified Nucleosides and Cancer. [Gisela Nass] -- This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, in Freiburg, West Germany.

The workshop was organized by. Nucleoside and nucleotide analogues are largely used in the treatment of cancer and viral infections.

A large number of novel compounds continue to be synthesized and evaluated both by academia Cited by: Keywords:Cancer, nucleoside analogues, PET, proliferation, radiosynthesis, treatment response, Uncontrolled cell proliferation, cytostatic chemodrugs, anatomical imaging modalities, radiolabeled nucleoside probes.

Abstract:Uncontrolled cell proliferation is an important hallmark of cancer. Nucleosides in Cancer Treatment book treatment with cytostatic chemodrugs usually. Today, a plethora of anti-viral 7 and anti-cancer agents 8 inspired by nucleosides are utilized in the clinic, represented by the modified nucleosides abacavir and gemcitabine and the modified bases fluorouracil and azathioprine, to name a few.

9,10 In addition to anti-viral and anti-cancer properties, several nucleosides are known to have anti. Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group.A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups.

In a nucleoside, the anomeric carbon. The clinical efficacy of anticancer nucleoside drugs depends on a complex interplay of transporters mediating entry of nucleoside drugs into cells, efflux mechanisms that remove drugs from. Pharmacology MCQ for Anti Cancer Chemotherapy Drugs.

ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER. All of the following antiviral drugs are the analogs of nucleosides, EXCEPT: a) Acyclovir.

b) Zidovudine. c) Saquinavir. d) Didanozine. Tick the drug, a derivative of adamantane: a) Didanozine. b) Rimantadine. c) Gancyclovir. d). Nucleoside Analogs in Cancer Therapy (Basic and Clinical Oncology) 1st Edition by Bruce D. Cheson (Editor), Michael J.

Keating (Editor), William Plunkett (Editor) & 0 more ISBN   Modified Nucleosides and Cancer: Recent Results in Cancer Research by Gisela Nass (Editor) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both : $ Abstract: This review will describe the recent advances in the field of aza-C-nucleosides with a particular emphasis on immucillins and related compounds.

The review will cover both chemical and biological aspects concerning their preparation and/or occurrence in Nature as well as their biological properties which include glycosidase, glycosyl. Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections.

This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, in Freiburg, West Germany.

The workshop was organized by Gisela Nass and sponsored by the Deutsche Forschungsgemeinschaft. Modified Nucleosides and Cancer. Editors (view affiliations) Gisela Nass; Book. 43 Citations; k Downloads; Part of the Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer book series (RECENTCANCER, volume 84) Log in to check access.

Buy eBook. USD Instant download; Readable on. Part C provides the reader with a comprehensive treatment of modified nucleosides as biochemical signals of neoplasia and normal metabolism.

The final volume, Part D, will present structural characterization of unknown nucleosides as well as extensive biochemical, chemical and physical properties of RNA and DNA nucleosides, as a database for.

Selected nucleosides for measurement of cancer marker and detection of newly synthesized DNA and RNA. Marker nucleosides such as 1-Methyl-adenosine, 5-Methyl-uridine, N 3-Methyl-uridine and Pseudouridine are found to be elevated in assocation with cancer [].Jena Bioscience offers proper nucleoside standards for their measurement.

ISBN: OCLC Number: Notes: "Lectures presented at the workshop Modified nucleosides and cancer held from 28 September to 2 October, in Freiburg, West Germany"--Preface. This treatment uses high-energy beams (similar to X-rays) to kill the cancer. It's often a choice when your cancer is low grade or still only in your prostate.

You also might have it after surgery. Radiotherapy is one of the treatments of choice in many types of cancer. Adjuvant treatments to radiotherapy try, on one hand, to enhance the response of tumor cells to radiation and, on the other hand, to reduce the side effects to normal cells.

Radiosensitizers are agents that increase the effect of radiation in tumor cells by trying not to increase side effects in normal tissues.The treatment of cancer is largely based on inhibition of cellular replication by cytostatic drugs.

These include alkylating agents, oncolytic antibiotics, topoisomerase inhibitors, antimetabolites and others. In the early s, the synthesis and cytostatic activity of purine nucleobase analogues was reported for the first time.

Cancer is responsible for millions of deaths worldwide, but most base diseases may be cured if detected early. Screening tests may be used to identify early-stage malignant neoplasms.

However, the major screening tool for prostate cancer, the prostate-specific antigen test, has unsuitable sensitivity. Since cancer cells may affect the pattern of consumption and excretion of nucleosides.